A 67-year-old cancer survivor from Orange County, Florida, named Frank Carter recently completed a remarkable journey down the Missouri River. He traveled over 2,341 miles with his faithful companion, a golden retriever named Amos. This journey followed Carter’s groundbreaking immunotherapy treatment, which marked a significant chapter in his battle against cancer.
Reports from the Moffitt Cancer Center and FOX 13 News highlight this adventurous achievement. Over 64 days, Carter navigated the longest river in the United States using a cedar-strip canoe he meticulously built by hand. The journey stretched from Montana to near St. Louis, Missouri, testing both Carter and Amos as they camped along the riverbank. Severe storms, high winds, and hail added to the challenges they faced.
Before his diagnosis, Carter was no stranger to long-distance adventures. In 2019, he spent five months hiking the Appalachian Trail. By 2020, he completed an eight-week bicycle ride from San Diego to New Smyrna Beach, Florida. However, in 2021, his physical endurance faced a new kind of test. After a routine 5K race, Carter experienced extreme fatigue. “I was wiped out. I just wasn’t recovering,” he shared with FOX 13 News. Seeking answers, Carter consulted his doctor and was soon diagnosed with a rare form of blood cancer, mantle cell lymphoma.
Carter underwent intensive chemotherapy, receiving 15 rounds of treatment in Orlando. Although his treatment was effective in reducing the cancer, subsequent exams indicated residual traces. Seeking further intervention, Carter turned to the Moffitt Cancer Center in Tampa for cutting-edge therapy.
The treatment involved CAR T-cell therapy, a form of immunotherapy that uses the patient’s own immune cells. These cells are extracted, genetically modified in a lab to identify cancer cells, and reintroduced into the patient’s body. This approach helped Carter achieve four years of being cancer-free. Dr. Michael Jain, an oncologist at Moffitt Cancer Center, explained the process: “We take those T-cells and genetically engineer them by putting something called a CAR into them. Now these T-cells can see the tumor and get rid of it.”
Throughout Carter’s recovery, Amos provided comforting companionship. “After my cancer diagnosis, I told myself I was going to beat this, and I really wanted a dog during the process,” Carter told Moffitt’s Endeavor publication. Amos joined him right before his first chemotherapy treatment and remained a source of unwavering support.
Khloe Quill, a lifestyle writer with Fox News Digital, and her team continue to explore diverse topics like travel, health, and food.

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