Christina Applegate Discusses Misdiagnosis and Ongoing Health Challenges

Christina Applegate has revealed that she was misdiagnosed with multiple sclerosis (MS) more than five years after announcing her diagnosis publicly. On her podcast MeSsy, with Jamie-Lynn Sigler, Applegate explained a doctor recently informed her she does not have MS.

Despite this change in diagnosis, Applegate continues to experience debilitating symptoms. She noted, “You don’t get misdiagnosed and then all of a sudden I’m better. If anything, I’ve gotten worse.”

The National Multiple Sclerosis Society explains that no single symptom, physical finding, or test can prove the presence of MS alone. Doctors must look for evidence of damage in different areas of the central nervous system. Additional tests may identify lesions or proteins in spinal fluid to establish that damage occurred at varying times. Doctors must exclude other diagnoses as well. Diagnostic tools include medical history, neurological exams, MRI imaging, blood tests, and cerebrospinal fluid analysis.

The diagnostic standards, known as the McDonald criteria, were revised in 2024 to enhance diagnostic accuracy. MS misdiagnosis is acknowledged as an issue. Misdiagnosed patients face prolonged health risks. Dr. Philip De Jager, a neurology professor, states, “MS remains a diagnosis of exclusion, meaning no single test definitively establishes the diagnosis.” He advised seeking a second opinion from specialized MS centers.

The National Multiple Sclerosis Society praised Applegate’s openness, saying it brings awareness to challenges faced during uncertain medical diagnoses. They emphasized the importance of advances in diagnostic criteria and research to help secure accurate diagnoses and proper care.

Understanding MS Symptoms

Dr. De Jager estimates that 1-4 per 1,000 people in the U.S. are affected by MS. He highlighted that genetic ancestry and geography influence prevalence. The National Multiple Sclerosis Society notes neurological exams assess various functions, such as balance and cognition.

Symptoms linked to MS include fatigue, numbness, weakness, bladder control issues, dizziness, and vertigo. No symptom alone proves MS, as other conditions may cause similar symptoms. Blood tests help rule out these conditions.

Applegate described having numbness, balance issues, and tingling in her limbs. In past interviews, she mentioned relying on a cane and a wheelchair for mobility.

Applegate’s Journey Through Misdiagnosis

Applegate initially shared her MS diagnosis in 2021. Upon ceasing an infusion treatment, no changes were detected in her B-cell count. Further investigation led to her doctor’s concluding, “Congratulations, you don’t have MS.” Despite others’ joy, Applegate was not happy, as her symptoms persisted.

She mentioned experiencing every symptom associated with MS. Numerous conditions mimic MS symptoms, but doctors suspect an alternate cause. “While misdiagnosis isn’t common, it can happen,” Dr. De Jager noted. He urged seeking additional opinions from specialized centers. A study found up to 19% of MS diagnoses may be incorrect.

The National Multiple Sclerosis Society stated some studies show misdiagnosis rates between 5% and 18%. They explained, “Multiple sclerosis is a complex disease. Symptoms vary and overlap with other conditions, making diagnosis lengthy.” No single test diagnoses MS. Clinicians assess history, symptoms, exams, MRI results, and other tests to differentiate symptoms’ causes.

If you have questions about symptoms, diagnosis, or treatment, seek advice from medical professionals.

Applegate voiced the emotional impact of her changing diagnosis. She stepped away from her podcast to process the news, feeling she let people down after raising MS awareness.

“I still use wheelchairs for doctor visits. Nothing magical changed with this new information,” she shared. Her doctors continue investigating her condition’s underlying cause since 2021.