Gene Continues to Influence Stress and Fat Storage Through Adulthood

A newly published study from the Weizmann Institute of Science in Israel has uncovered the long-lasting role of a gene known as Orthopedia, or Otp, in managing stress and fat storage. This gene, previously recognized for its importance in brain development before birth, remains active into adulthood. The findings, published in Endocrinology, offer insights into the links between stress and weight gain.

Ongoing Role of Orthopedia

Otp is a transcription factor that operates within the cell nucleus. It is crucial for building the hypothalamus, the brain area responsible for controlling essential functions such as hunger, sleep, and stress responses. The study led by Professor Gil Levkowitz, alongside Professor Alon Chen, explored the gene’s function in adult brains using mice. They developed a genetic tool to deactivate Otp in adult brain cells, leaving initial brain development intact.

Results revealed that mice without active Otp produced excessive amounts of stress hormones like corticosterone. They exhibited behaviors similar to depression, such as avoiding challenges and easily giving up. Metabolically, these mice experienced reduced thyroid hormone levels, decreased body temperature, and increased cholesterol. Although their weight remained constant, they stored more body fat and reacted poorly to hunger signals.

Evolutionary Adaptation

The researchers propose that evolution has adapted Otp to serve dual purposes. During development, Otp aids in brain cell specialization. In adulthood, it shifts to managing stress responses and energy usage, sometimes balancing conflicting tasks like promoting hunger while increasing energy expenditure. Professor Levkowitz noted the significance of understanding Otp’s dual role for developing treatments for stress and metabolic disorders.

Comprehensive Implications

Clinical psychologist Dr. Jessica McCarthy detailed how Otp acts as an active regulator of adult hypothalamic function, managing stress and metabolic signals. She emphasized the study’s illustration of the interconnection between regulatory systems, highlighting the complexity underlying observable behaviors. Dr. McCarthy advises regular health check-ups to help identify physiological factors affecting behavior.

For further information, the study is documented by Levkowitz, G., Chen, A., et al. (2026) in Endocrinology. For inquiries about the research, Newsweek can be contacted through editors Sirena Bergman and Cristina Diciu.