Rise in Diphenhydramine Abuse Among Teens Sparks Concern

Poison center records reveal a growing trend among America’s youth in abusing common over-the-counter medications. A recent advisory from America’s Poison Centers, representing 53 centers across the nation, highlights a significant increase in diphenhydramine abuse among teenagers aged 13 to 19. Diphenhydramine is an ingredient commonly found in allergy and sleep medications like Benadryl and Zzzquil.

From 2024 to 2025, there was a 5.1% increase in total exposure to any substance among teens. However, cases involving diphenhydramine surged more drastically, rising by 32% from 10,068 to 13,284 cases. In 2026, 13% of diphenhydramine-related cases involved intentional misuse, increasing from 7.3% in 2020. The numbers suggest the trend is ongoing, with the first five months of 2026 already reporting 6,179 cases involving diphenhydramine.

The advisory clarifies that these exposures are predominantly due to recreational misuse rather than accidental overuse. Misusing diphenhydramine can lead to severe and life-threatening effects on the brain and heart. Symptoms of poisoning include drowsiness, agitation, nausea, vomiting, rapid heartbeat, hallucinations, seizures, and unconsciousness.

“Talk with teens about the risks of misusing medications, including serious health effects and poisoning,” the advisory suggests.

To avoid such issues, America’s Poison Centers recommend storing medications securely, out of children and teens’ reach, and following label instructions closely. Social media trends or challenges that promote unsafe use of medications should be carefully monitored.

Kenvue, the manufacturer of Benadryl, expressed concern over the dangerous social media trend encouraging misuse of diphenhydramine products. They emphasized the importance of prioritizing users’ health and safety. Kenvue is collaborating with social media platforms to remove harmful content and spread awareness about safe medication use and storage.

Mary Leonard from the Consumer Healthcare Products Association described the report as “deeply concerning.” She stressed that OTC medicines should never be used recreationally, highlighting the vital role of the Drug Facts label in communicating safe usage, including dosing guidelines.

• Report social media content that promotes this trend.
• Store medications out of children’s reach, ideally in locked cabinets.
• Read and follow instructions carefully, and educate children on safe use.

Kenvue advises users to visit Benadryl.com for dosing instructions and safety information, urging consultation with healthcare professionals for any further questions.